Part VIII - Human Genetics

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Question Chapter Year
What are mutations? Describe their consequences (DNB 2010/1)5+5962010
What are mitochondrial genes? How are they transmitted? Briefly discuss diseases transmitted by them? (DNB 2011/2)2+2+6972011
Enumerate classic and non-classic forms of genetic inheritance. Discuss in brief the characteristics of autosomal recessive inheritance. Illustrate with a pedigree chart (DNB 2013/1)5+3+2,(DNB 2013/2)2+2+6972013
Describe the symbols used in pedigree chart. Draw pedigree charts over 4 generations depicting a) X-linked dominant disease b) X-linked recessive disease (DNB 2016/1)4+3+3972016
Draw pedigree chart for autosomal dominant inheritance pattern of non-consanguinous parents (DNB 2018/1)5972018
Patterns of genetic inheritance (DNB 2018/2)5972018
Diagrammatically illustrate principles of mode of inheritance of genetic disorders (DNB 2019/2)6972019
Briefly describe the important attributes of various patterns of genetic inheritance (DNB 2020/2)6972020
Pedigree chart and patterns of inheritance (DNB 2023/1)5972023
Modes of inheritance (DCH 2023/2)5972023
Briefly discuss the principles of genetic counselling. Outline the counselling of a family with a child with Down's syndrome (DNB 2004/2) 5+5982004
Gene Therapy in Children (DNB 2006/1)10982006
Gene therapy (DNB 2007/1)5982007
Primary and secondary prevention of genetic disorders (DNB 2016/1)5+5982016
Principles of gene therapy (DNB 2020/2)5, (DNB 2023/1)5982020
Gene therapy (DNB 2023/2)5982023
CRISPR gene editing technology for child health (DNB 2021/1)5982021
Next-generation sequencing and its indications (DNB 2021/1)5982021
Indication of Next Generation Sequencing in pediatric hemato-oncology (DNB 2022/1)5982022
Enzyme Replacement Therapy (DNB 2021/2)5, (DNB 2023/2)5, (DNB 2024/2)5982021
Clinical Exome sequencing (DNB 2022/2)5982022
Indications of genetic counselling (DNB 2023/2)5982023
Define translocation. Write the inheritance pattern for translocations. Describe clinical features of any one translocation disorder (DNB 2016/1)6992016
Discuss the genotypic and phenotypic features of Turner's syndrome (DNB 2011/1)4+6992011
Disorders of Genetic imprinting (DNB 2022/2)5992022
Genomic imprinting (DCH 2023/2)5992023
Dysmorphic child (DNB 1994/2)151001994
Classification of birth defects (DNB 2022/1)51002022
Define craniosynostosis and its types. Name specic syndromes associated with craniosynostosis. Describe the clinical characteristics of common types of craniosynostosis (DNB 2013/2)3+3+41012013
Craniosynostosis (DNB 2020/2)51012020
Define clinical exome sequencing (CES) and its uses (DNB 2025/1)5982025
Cell-free DNA prenatal screening test (DNB 2024/2)5982024

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